個人簡介

王以瑄 博士，南京航空航天大學伟德 官网，長空博士後，助理教授。研究方向圍繞生物信息計算與數字健康；研究工作聚焦多靶标多終點聯立的泛癌免疫治療臨床決策支持；主持國家自然科學基金青年項目一項。

學術成果

1. Accurately estimating the length distributions of genomic micro-satellites by tumor purity deconvolution, BMC Bioinformatics, 2020, 21(S2): 82, doi: 10.1186/s12859-020-3349-5
2. A graph-based algorithm for estimating clonal haplotypes of tumor sample from sequencing data , BMC Medical Genomics, 2019, 12(S1): 27, doi: 10.1186/s12920-018-0457-4
3. CMSI: A Bayesian model for estimating clonal micro-satellites instability from NGS data, Cancer Research, 79(13 Suppl): Abstract nr LB-215, doi: 10.1158/1538-7445.AM2019-LB-215
4. A Joint Model Considering Measurement Errors for Optimally Identifying Tumor Mutation Burden Threshold, Frontiers in Genetics, 2022, 13: 915839, doi: 10.3389/fgene.2022.915839
5. TMBcat: A multi-endpoint p-value criterion on different discrepancy metrics for superiorly inferring tumor mutation burden thresholds, Frontiers in Immunology, 2022, 13: 995180, doi: 10.3389/fimmu.2022.995180
6. TMBserval: a statistical explainable learning model reveals weighted tumor mutation burden better categorizing therapeutic benefits, Frontiers in Immunology, 2023, 14:1151755, doi: 10.3389/fimmu.2023.1151755

承擔項目

1. 國家自然科學基金青年項目，62302215，多維動态生物标志物輔助腫瘤免疫治療多終點融合決策研究，2024/1-2026/12，主持；
2. 南京航空航天大學校人才科研啟動基金，1003-YAH23029，主持